Two sample MR report
HLA-DQA1_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 30 | -0.1818508 | 0.1153037 | 0.1259946 |
| Weighted median | 30 | 0.1549526 | 0.0159115 | 0.0000000 |
| Inverse variance weighted | 30 | 0.1325029 | 0.0197283 | 0.0000000 |
| Simple mode | 30 | 0.2003204 | 0.0246274 | 0.0000000 |
| Weighted mode | 30 | 0.1921152 | 0.0403492 | 0.0000492 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 126.9344 | 28 | 0 |
| Inverse variance weighted | 161.4527 | 29 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0949856 | 0.0344226 | 0.010093 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002872 | 8e-07 | TRUE | 0.126356 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
